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OLS Field Name OLS Field Data
Main Title Mutagenicity of the Fractionated Organic Emissions from Diesel, Cigarette Smoke Condensate, Coke Oven, and Roofing Tar in the Ames Assay.
Author Austin, A. C. ; Claxton, L. D. ; Lewtas, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/192;
Stock Number PB86-118809
Additional Subjects Toxicity ; Air pollution ; Exhaust emissions ; Mutagens ; Bioassay ; Coking ; Roofing materials ; Industrial wastes ; Combustion products ; Aromatic polycyclic hydrocarbons ; Sources ; Chemical analysis ; Reprints ; Ames test ; Stationary sources ; Air pollution detection ; Diesel engine exhaust ; Cigarette smoke ; Polycyclic organic matter
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NTIS  PB86-118809 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 19p
Abstract Mobile and stationary sources emit particle-bound organics that have demonstrated mutagenicity. The objective of this study was to measure the mutagenicity of the fractionated organic emissions from diesel, cigarette smoke condensate (CSC), coke oven and roofing tar in the Ames assay. This study demonstrated significant biological differences among the four emission sources. Within each source, the relative mutagenicity of each fraction was significantly different in the presence and absence of an exogenous metabolic activation. In the diesel sample, over 90% of the mutagenic activity is located in the aromatic and polar neutral (PN) fractions, and a significant portion of this activity can be accounted for by nitro-PNAs. Most of the mutagenicity of the coke oven main sample was found in the BASE and PN fractions which contained aromatic amines and nitrogen heterocycles. The CSC sample also had a high percent of the mutagenic activity in the BASE fraction. Chemical analysis however, indicates that the components in the CSC differed significantly from those of the coke oven main sample. The roofing tar sample contained aromatic and polar mutagenic constituents that were not NO2-PNAs. Although the specific mutagens in these different sources are not identical, they all cause frameshift mutations and appear to be compounds that could be classified as polycyclic organic matter (POM).
Supplementary Notes Pub. in Environmental Mutagenesis 7, p471-487 Aug 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Mutagenicity of the Fractionated Organic Emissions from Diesel, Cigarette Smoke Condensate, Coke Oven, and Roofing Tar in the Ames Assay.
PUB Date Free Form 1985
Category Codes 6T; 7D; 6A; 68A; 57Y; 99A; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 603115860
Origin NTIS
Type CAT