Main Title |
Results of Range Finding Toxicological Test on Three Samples of 4-tert Octyl Phenol. |
CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
2000 |
Report Number |
40-5462011 |
Stock Number |
OTS0527942 |
Additional Subjects |
Toxicology ;
Health effects ;
4-(1 ;
1 ;
3 ;
3-tetramethylbutyl)phenol ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Primary Eye Irritation ;
Rabbits ;
Dermal ;
Primary Dermal Irritation ;
Toxic substances ;
Laboratory animals ;
CAS No 140-66-9
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0527942 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
4-(1,1,3,3-Tetramethylbutyl)phenol (TMBP) was evaluated for acute toxic effects. Summary information from 3 acute oral toxicity tests in rats (2/group) fed dietary doses of 1.0, 1.26 1.58, or 2.0 g/kg led to mortality at 1.26 g/kg and above, and initial weight loss and slight retrograde degeneration of the kidney was seen in 1.58 and 2.0 mg/kg groups. No observable effects were noted at 1.0 g/kg. Summary reports of 3 eye irritation studies in rabbits indicate that 1% TMBP in propylene glycol administered to unwashed or washed eyes is slightly irritating and painful. Instillation of 10% and 100%concentrations showed increasing severity of effects, including corneal burns. Summary reports of primary skin irritation tests in rabbits indicate treatment-related irritation occurs with exposure to 1%, 10%, and 100% TMBP in 50B (not described). |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
2000 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028802980 |
Origin |
NTIS |
Type |
CAT |