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OLS Field Name OLS Field Data
Main Title Comparative In vitro Percutaneous Absorption of p-Substituted Phenols through Rat Skin Using Static and Flow-Through Diffusion Systems.
Author Hughes, M. F. ; Shrivastava, S. P. ; Fisher, H. L. ; Hall, L. L. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher cMay 93
Year Published 1993
Report Number EPA-68-02-4450; EPA/600/J-93/416;
Stock Number PB94-101573
Additional Subjects Phenols ; Skin(Anatomy) ; Dermal absorption ; Comparison ; In vitro analysis ; Diffusion ; Rats ; Graphs(Charts) ; Reprints ;
Holdings
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Status
NTIS  PB94-101573 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/27/1994
Collation 8p
Abstract The objective of this study was to determine the in vitro percutaneous absorption of (14)C-phenol and eight p-substituted derivatives and to examine the variability of this data. Two diffusion systems, the static and flow-through, were used. Clipped dorsal skin was removed from female F344 rats (90 days old), dermatomed to a thickness of approximately 350 micrometer, placed in a diffusion cell and treated with chemical (4 microgram/sq cm, in ethanol). The cumulative absorption at 72 hr for the phenols in both systems ranged from 15.4 to 97.6%. Greater than 70% of the chemical was absorbed in both systems when the chemical had a log P value between 1.4-3.5. Significant differences in percent absorption between the two diffusion systems were observed with 5 of the compounds. Absorption of acetamidophenol, chlorophenol and cyanophenol were significantly lower in the static system. Absorption of phenol and heptyloxyphenol were significantly lower in the flow-through system. The most variable absorption data in both systems were with the phenols that were absorbed the least (70%). These same chemicals were also on the extremes of the log P scale for the phenols examined. Controlling for the variability of in vitro percutaneous absorption of chemicals is necessary when using the data for human risk assessment.
Supplementary Notes Pub. in Toxicology In vitro, v7 n3 p221-227 May 93. See also PB90-215898. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Comparative In vitro Percutaneous Absorption of p-Substituted Phenols through Rat Skin Using Static and Flow-Through Diffusion Systems.
Category Codes 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 402522793
Origin NTIS
Type CAT