||Evaluation of the Dermal Carcinogenic Potential of Pentaerythritol Acrylate-HF with Attachments and Cover Letter dated 07/28/88.
||Union Carbide Corp., Danbury, CT. ;Carnegie-Mellon Inst. of Research, Pittsburgh, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||2 Aug 1988
Dermal absorption ;
Chemical hygine ;
Malignant neoplasms ;
Pentaerythritol aerylate-HF ;
Union Carbide Corporation(Trademark) ;
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||Forty C3H/HeJ male mice were painted 3 times per week for their lifespan on the skin of the back, clipped free of fur, with pentaerythritol acrylate-HF as a 15% dilution in acetone at an average dose of 0.0026 grass pentaerythritol acrylate-HF/mouse/application. A negative control group of 40 C3H/HeJ male mice received repeated skin paintings of undiluted acetone at an average dose of 0.012 grams/mouse/application. No skin tumors were observed in the group of mice painted with pentaerythritol acrylate-HF. One mouse in the group painted with acetone had a histologically verified squamous cell carcinoma of the skin near the right eye which may or may not have been due to treatment.
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