Main Title |
Biochemical and Morphological Validation of a Rodent Model of OPIDN. |
Author |
Padilla, S. ;
Veronesi, B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1988 |
Report Number |
EPA/600/D-88/049; |
Stock Number |
PB88-184650 |
Additional Subjects |
Rats ;
Laboratory animals ;
Nervous system disorders ;
Phosphorus organic compounds ;
Screening ;
Morphology ;
Tests ;
Pathology ;
Damage ;
Exposure ;
Biochemistry ;
Enzymes ;
Indicator species ;
Phosphites ;
Esterases ;
Phosphorus organic compounds ;
Triphenyl phosphite
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-184650 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
24p |
Abstract |
The paper describes six years of research designed to validate the use of the rat as a viable alternative to the hen for screening and mechanistic studies of neuropathic OP compounds. To date the results indicate that if morphological rather than behavioral endpoints are used, the rat may be a more valid indicator of OPIDN. The authors must, however, test the rat with a wider variety of test OPs to substantiate further the NTE/pathology relationship. Over and above the regulatory considerations, the rat, can be successfully used to address, the mechanistic questions of OPIDN and will hopefully be used to unravel those events occurring between OP exposure and the onset of pathological damage. |
PUB Date Free Form |
Mar 88 |
Category Codes |
57E; 57P; 98E |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
814620781 |
Origin |
NTIS |
Type |
CAT |