Main Title |
The Histone Code and Beyond New Approaches to Cancer Therapy / [electronic resource] : |
Type |
EBOOK |
Author |
Berger, S. L.
|
Other Authors |
|
Publisher |
Springer Berlin Heidelberg, |
Year Published |
2006 |
Call Number |
QD415-436 |
ISBN |
9783540376330 |
Subjects |
Life sciences ;
Oncology ;
Biochemistry ;
Cytology
|
Internet Access |
|
Collation |
XIV, 215 p. online resource. |
Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
Contents Notes |
The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development -- Nucleosome Structure and Function -- The Role of Snf2-Related Proteins in Cancer -- Imitation Switch Complexes -- How Is Epigenetic Information on Chromatin Inherited After DNA Replication? -- Polycomb Silencing Mechanisms and Genomic Programming -- CpG Island Methylation and Histone Modifications: Biology and Clinical Significance -- Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae -- Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis -- Role of Ubiquitin-Like Proteins in Transcriptional Regulation -- Interplay of the SUMO and MAP Kinase Pathways. Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book. |
Place Published |
Berlin, Heidelberg |
Corporate Au Added Ent |
SpringerLink (Online service) |
Title Ser Add Ent |
Ernst Schering Research Foundation Workshop, 57 |
Host Item Entry |
Springer eBooks |
PUB Date Free Form |
2006 |
Series Title Untraced |
Ernst Schering Research Foundation Workshop, 57 |
BIB Level |
m |
Medium |
computer |
Content |
text |
Carrier |
online resource |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20141128022112 |
Language |
eng |
Origin |
SPRINGER |
Type |
EBOOK |
OCLC Rec Leader |
03360nam a22005055i 45 |