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Main Title Textbook of Cell Signalling in Cancer An Educational Approach / [electronic resource] :
Type EBOOK
Author Robert, Jacques.
Publisher Springer International Publishing : Imprint: Springer,
Year Published 2015
Call Number RC261-271
ISBN 9783319143408
Subjects Medicine ; Oncology ; Toxicology ; Cytology
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-3-319-14340-8
Collation XXIII, 328 p. 126 illus., 122 illus. in color. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Growth Factors and Tyrosine Kinase Receptors -- MAP Kinases Pathway -- Phosphatidylinositol 3-Kinase Pathway -- Cytokine Pathway -- TGFβ Pathway -- G-proteins-coupled Receptors -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- Integrins -- Semaphorins and Adhesion Molecules -- Toll-like Receptors, Interleukin 1 (IL1) and NFκB -- Lymphocyte Receptors Pathways -- Nuclear Receptors Pathways -- Ion Channels-coupled Receptors -- Signalling by Oxygen and Nitric Oxide -- Cell Cycle Control -- Apoptosis Induction and Regulation. This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the master's courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.
Place Published Cham
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2015
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20150217150621
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 03273nam a22004695i 45