||Initial Submission: Letter from Rohm and Haas Company to USEPA re: Neurotoxicity in Female Rats with Ethyl 4,4,4-trifluoroaceto-acetate, in Preliminary Results of Acute Study, with Cover Letter dated 10/05/99.
||Rohm and Haas Co., Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||7 Oct 1999
Corn oil ;
Laboratory animals ;
Ethyl 4,4,44rifluoroacetoacetate ;
Acute toxicity tests ;
CAS No. 372-31-6
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This letter transmits preliminary results of an acute toxicity test indicating neurotoxic effects to female rats for ethyl 4,4,44rifluoroacetoacetate (CAS No. 372-31-6). Ethyl 4,4,4-trifluoroacetoacetate (ETFAA) was suspended in corn oil and administered by oral gavage to seven groups of six female rats/group at dose levels of 0, 25, 100, 17.5, 250, 500, or 750 mg/kg of body weight at a constant volume of 5 ml/kg. Clinical signs indicative of neurotoxicity (i.e., ataxia, tremors, fasciculations, prostration, salivation) were observed at 250 mg/kg and above after multiple doses.
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