Main Title |
Neurobehavioral Effects of Triadimefon, a Triazole Fungicide, in Male and Female Rats. |
Author |
Moser, V. C. ;
Macphail, R. C. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/208; |
Stock Number |
PB90-146234 |
Additional Subjects |
Animal behavior ;
Behavior disorders ;
Toxicity ;
Rats ;
Fungicides ;
Exposure ;
Graphs(Charts) ;
Dosimetry ;
Body temperature ;
Males ;
Females ;
Reprints ;
Triadimefon ;
Operant conditioning ;
Motor activity ;
Dose-response relationships
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-146234 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Triadimefon is a widely used systemic fungicide, yet there is little published information on its effects in mammals. The study describes the effects of triadimefon in male and female rats using a functional observational battery (FOB), motor activity (measured in a figure-eight maze), and operant performance (responding under a fixed-interval 3-min schedule). For the FOB, Long-Evans hooded rats were tested immediately before dosing and 0.5, 4, 24, and 48 hr after dosing with either vehicle, 30, 100, or 300 mg/kg triadimefon i.p. Prominent effects of triadimefon 100 and 300 mg/kg included increased arousal, stereotypes involving repetitive sniffing, head bobbing, and pacing, and self-mutilation. Dose-related handling-induced convulsions, changes in reflexes and sensory reactivity, hypothermia, and body weight loss were also significant findings. Doses of 30, 75, and 150 mg/kg triadimefon increased figure-eight maze activity whereas 300 mg/kg decreased activity. Thus triadimefon produced a neurotoxic syndrome which is unprecedented in pesticides and is similar in many aspects to that produced by CNS stimulants. |
Supplementary Notes |
Pub. in Neurotoxicology and Teralogy, v11 p285-293 1989. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Neurobehavioral Effects of Triadimefon, a Triazole Fungicide, in Male and Female Rats. |
Category Codes |
57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
200/04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
007530479 |
Origin |
NTIS |
Type |
CAT |