| Main Title |
Initial Submission: Combined Oncogenicity and Toxicity Study of N-(2,4-Difluorophenyl) -2-(3-(Trifluoromethyl)Phenoy) 3-Pyridine-Carboximide in Rats with Cover Letter dated 08/13/1992. |
| CORP Author |
Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
EPA-OTS-88-920009450 |
| Stock Number |
OTS0571106 |
| Additional Subjects |
Toxicology ;
Health effects ;
N-(2 ;
4-difluorophenyl) -2-(3-(trifluoromethyl) phenoxy)-3-pyr ;
Chronic toxicity ;
Mammals ;
Rats ;
Combined chronic toxicity ;
Combined chronic carcinogenicity ;
Oral ;
Diet ;
CAS No 83164-33-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571106 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
4p |
| Abstract |
This study was submitted under Section 8(e) because of increased severity of testicular degeneration and a significant increase in the incidence of skin fibromas for the high dose males. Test material was administered to F-344 rats (50/sex/group) via admixture into the diet at concentrations of 0, 500, 2500, or 12,500 ppm for approximately 104 weeks. A dose-related effect on body weights was observed throughout the study with high dose males showing approximately a 20 to 30% depression in body weight gain. Histopathological examination revealed a statistically significant increase in the incidence of a lack of sperm in the epididymides and extramedullary hemopoiesis and hemosiderosis in the spleen for high dose males. The findings in the epididymides was not clearly associated with histopathological changes in the testes related to treatment, but the labDratOry reported treated males sacrificed at study termination had an increased severity of testicular degeneration. A significant lucrease in the incidence of skin fibromas for the high dose males was also noted. However, this Increase is well within historical control ranges of 4 to 26% for this tumor. No treatment-related microscopic lesions were observed in females. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
8 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018801530 |
| Origin |
NTIS |
| Type |
CAT |
