| Main Title |
Letter from Ethyl Corp to US EPA Submitting Additional Preliminary Results from 2-year Bioassay on Diethyltoluene Diamine. |
| CORP Author |
Ethyl Corp., Baton Rouge, LA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
89-910000139 |
| Stock Number |
OTS0510588-4 |
| Additional Subjects |
Toxicology ;
Health effects ;
Diethyltoluene Diamine ;
Chronic Toxicity ;
Carcinogenicity ;
Mammals ;
Rats ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 68479-98-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510588-4 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
3p |
| Abstract |
Diethyltoluene diamine (68479-98-1) was evaluated in a two-year dietary oncogenicity study on Sprague-Dawley rats (50/sex/group) fed diets containing 0, 10, 35 and 70 ppm of the test material. A statistically significant increase of the incidence in hepatocellular carcinomas and hepatic proliferative lesions (eosinophilic and basophilic foci), as well as follicular cell adenomas and follicular cell hypertrophy of the thyroid were observed in the high dose males. High dose males also showed: an increase in multifocal acinar atrophy accompanied by interstitial fibrosis and fatty infiltration in the pancreas; bilateral cataracts and moderate to severe keratitis of the eyes; increased incidence of multifocal medullary hyperplasia in the adrenals. One follicular cell carcinoma was present in a low dose male. Follicular cell hyperplasia and follicular cysts were increased in the thyroids of the mid and high dose males. Focal medullary hyperplasia was also seen among control rats. |
| Supplementary Notes |
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| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801590 |
| Origin |
NTIS |
| Type |
CAT |
