||Human Subject Experiments to Estimate Reentry Periods for Monocrotophos-Treated Tobacco.
Guthrie, F. E. ;
Domanski, J. J. ;
Chasson, A. L. ;
Bradway, D. E. ;
Monroe., R. J. ;
||Health Effects Research Lab., Research Triangle Park, N.C. ;North Carolina State Univ., Raleigh. Dept. of Entomology.
Industrial hygiene ;
Cholinesterase inhibitors ;
Laboratory animals ;
Experimental data ;
Nitrogen organic compounds ;
Phosphorous organic compounds ;
Agricultural workers ;
Pesticide residues ;
Occupational safety and health ;
Phosphoric acid/dimethyl ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Thirteen to fifteen human volunteers worked for eight-hr periods in tobacco fields treated 96, 72, and 48 hr previously with monocrotophos (3-hydroxy-N-methyl-cis-crotonamide dimethyl phosphate). At the 48-hr reentry period, during which time no rainfall occurred, both post-exposure plasma and red blood cell cholinesterase levels of the worker group were depressed from pre-exposure levels although the decline was less than 9% in both cases. Rainfall in excess of one inch fell during the 96- and 72-hr reentry intervals, and no important change in cholinesterase levels was noted. Experiments with mice were in general agreement with the human tests. Dimethyl phosphoric acid in urine of the worker group collected prior to, and three hr after, exposure was unchanged in all cases. Rain appeared to have markedly reduced dislodgable residues.
||Prepared in cooperation with North Carolina State Univ., Raleigh. Dept. of Entomology.
||Pub. in Archives of Environmental Contamination and Toxicology, v4 p217-225 1976.
|NTIS Title Notes
||Reprint: Human Subject Experiments to Estimate Reentry Periods for Monocrotophos-Treated Tobacco.
|PUB Date Free Form
||7 Oct 74
||6T; 6J; 57Y; 57U; 68G; 68E
||Not available NTIS