||Direct Effect of Paraoxon on Erythrocyte Metabolism as Measured by O2 Uptake.
Santolucito, J. A. ;
Whitcomb., E. R. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Phosphorus organic compounds ;
Cholinesterase inhibitors ;
Blood cells ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In studying the effects of anticholinesterase compounds, the blood has been considered primarily as an index of exposure; however, there are reports in the literature which suggest that anticholinesterase compounds may have an effect on the erythrocyte itself. This study was undertaken to measure the metabolic O2 uptake of rabbit erythrocytes and the rate of erythrocyte removal from general circulation after exposure to paraoxon. There was no apparent acceleration of removal rate of the paraoxon treated erythrocyte in the general circulation. These results suggested that paraoxon acted on -SH groups in blocking O2 uptake.
||Pub. in Toxicology and Applied Pharmacology 19(2) p397, Jun 71.
||Included in the report, Journal Articles on Toxicology. Group 1, PB-277 586.
||Reprint: Direct Effect of Paraoxon on Erythrocyte Metabolism as Measured by O2 Uptake,
|PUB Date Free Form
||(Order as PB-277 586, MF A01)