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OLS Field Name OLS Field Data
Main Title Biological Variability and the Influence of Stress on Cholinesterase Activity.
Author Rattner, B. A. ; Fairbrother., A. ;
CORP Author Patuxent Wildlife Research Center, Laurel, MD.;Corvallis Environmental Research Lab., OR.
Publisher 1990
Year Published 1990
Report Number EPA/600/D-90/072;
Stock Number PB90-246307
Additional Subjects Stress(Physiology) ; Cholinesterase ; Metabolism ; Vertebrates ; Toxicology ; Blood proteins ; Cholinesterase inhibitors ; Pesticides ; Reproduction(Biology) ; Circadian rhythms ; Genetics ; Carbamates ; Reprints ; Brain chemistry ; Biological markers ; Organophosphorus insecticides ; Species specificity
Library Call Number Additional Info Location Last
NTIS  PB90-246307 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/03/1990
Collation 34p
Abstract Normal activity of brain and plasma cholinesterase in higher vertebrates is known to be affected by age, genetics, circadian rhythms, sex, endocrine function, and reproductive status. Various stressors (e.g., nutritional plane, ambient temperature, disease) have also been demonstrated to alter cholinesterase activity in birds and mammals. Naturally-occurring and stress-induced variation in cholinesterase activity should be considered when the biomarker is used to assess exposure to organophosphorus and carbamate pesticides. In addition to pesticide metabolism (activation and detoxication) and physiological condition, basal cholinesterase activity may also be a determinant of sensitivity to cholinesterase-inhibiting pesticides. The present review examines the biological and stress-induced sources of variability in brain and blood cholinesterase activity of non-exposed vertebrates, and the toxicological and hazard assessment ramifications of such variability.
Supplementary Notes Pub. in Chemicals in Agriculture series, 1990. Sponsored by Corvallis Environmental Research Lab., OR.
Title Annotations Reprint: Biological Variability and the Influence of Stress on Cholinesterase Activity.
Category Codes 57W; 57B; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/02
Document Type NT
Cataloging Source NTIS/MT
Control Number 024228845
Origin NTIS
Type CAT