||Comparative Stimulation of gamma HCH Metabolism by Pretreatment of Rats with gamma HCH, DDT, and DDT + gamma HCH.
Chadwick, R. W. ;
Cranmer, M. F. ;
Peoples., A. J. ;
||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Laboratory animals ;
Experimental data ;
Chlorine organic compounds ;
Labeled substances ;
Physiological effects ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Pretreatment of rats with gamma HCH, DDT, and DDT + gamma HCH accelerates the metabolism of gamma HCH. A single oral dose of 14C gamma HCH was administered to all animals after 2 wk of pretreatment. The treated rats excreted significantly more radioactivity and stored significantly less 14C gamma HCH than the control animals. In addition to significantly larger livers, the treated rats exhibited higher cytochrome P-450 content and greater in vitro enzyme activity than the control animals. The self-induction of gamma HCH metabolism, which has not previously been reported, could be of major importance in establishing a steady-state relationship between exposure and storage of such pesticides by mammals. Both quantitative and qualitative differences in gamma HCH metabolism are observed between the treated groups of rats. DDT pretreatment results in a 35% higher excretion of radioactivity than gamma HCH pretreatment.
||Pub. in Toxicology and Applied Pharmacology 18, p685-695 1971.
||Included in the report, Journal Articles on Pesticide Biology, PB-275 918.
||Reprint: Comparative Stimulation of gamma HCH Metabolism by Pretreatment of Rats with gamma HCH, DDT, and DDT + gamma HCH,
|PUB Date Free Form
||18 Jun 70
||6T; 6O; 57Y; 57Q
||(Order as PB-275 918, MF A01)