||Brain-Acetylcholinesterase Inhibition in a Marine Teleost during Lethal and Sublethal Exposures to 1,2-Dibromo-2,2-dichloroethyl Dimethyl Phosphate (Naled) in Seawater.
Coppage, David L. ;
Matthews., Edward ;
||Environmental Protection Agency, Gulf Breeze, Fla. Gulf Breeze Environmental Research Lab.
||GULF BREEZE CONTRIB-199;
Cholinesterase inhibitors ;
Phosphorus organic compounds ;
Lethal dosage ;
Bromine organic compounds ;
Chlorine organic compounds ;
Toxic diseases ;
Physiological effects ;
Marine fishes ;
Sublethal dosage ;
Lagodon rhomboides ;
Toxic substances ;
Water pollution effects(Animals)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||To determine if brain-acetylcholinesterase (AChE) inhibition in a marine teleost Lagodon rhomboides (pinfish) by an organophosphate pesticide (naled) is specific enough to diagnose anticholinesterase poisoning, brain-AChE inhibition by sublethal exposure in seawater was compared to brain-AChE inhigition caused by lethal exposure. A sublethal exposure did not inhibit brain-AChE as much as lethal exposure in periods of 24, 48, and 72 hr. Consistent levels of inhibition (84-89% inhibition) occurred when 40-60% of an exposed populaion of pinfish was killed. This correlation of brain-AChE inhibition with exposure and death in a fish population shows that brain-AChE measurements are of value in diagnosing anticholinesterase poisoning in a marine fish.
||Pub. in Toxicology and Applied Pharmacology 31, p128-133 1975.
||Included in the report, Journal Articles on Toxicology, Group 16, PB-280 830.
||Reprint: Brain-Acetylcholinesterase Inhibition in a Marine Teleost during Lethal and Sublethal Exposures to 1,2-Dibromo-2,2-dichloroethyl Dimethyl Phosphate (Naled) in Seawater,
|PUB Date Free Form
||27 Mar 74
||6T; 8A; 57Y; 68E; 47D; 68D
||(Order as PB-280 830, MF A01)