||Toxicity of Chlorine Dioxide in Drinking Water.
Abdel-Rahman, M. S. ;
Couri, D. ;
Bull, R. J. ;
||New Jersey Medical School, Newark. Dept. of Pharmacology. ;Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Chlorine oxides ;
Water treatment ;
Blood cells ;
Chlorine dioxide ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Chlorine dioxide (ClO2) is currently being considered as an alternate to chlorine as a disinfectant for public water supplies. Studies were conducted to determine the toxicity of ClO2 (0, 1, 10, 100, 1000 mg/L) and its metabolites, ClO2(-1) and ClO3(-1) (10, 100 mg/L) in drinking water in rats. After 9 months treatment the osmotic fragility of the red blood cells was decreased in all treatment groups, while a decreased blood glutathione was only observed in the metabolite groups. At 2, 4, and 6 months no significant hematologic changes were noted in treated rats compared to control. However, after 9 months RBC counts, hematocrit, and hemoglobin were decreased in all treatment groups. ClO2, ClO2(-1), and ClO3(-1) administered chronically in drinking water for 3 months inhibited the incorporation of (3)H-thymidine into nuclei of rat tests. The treatment with Cl compounds decreased rat body weight in all groups after 10 and 11 months treatment.
||Prepared in cooperation with Ohio State Univ., Columbus. Coll. of Medicine.
||Pub. in Jnl. of the American College of Toxicology, v3 n4 p277-284 1984.
|NTIS Title Notes
||Reprint: Toxicity of Chlorine Dioxide in Drinking Water.
|PUB Date Free Form
||13B; 6T; 6C; 50B; 57Y; 57Z
||Not available NTIS