||Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat.
Harrington, R. M. ;
Shertzer, H. G. ;
Bercz, J. P. ;
||Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ. Medical Center, OH.
Chlorine dioxide ;
Laboratory animals ;
Water pollution effects(Animals)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Aqueous chlorine dioxide (ClO2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine.
||Prepared in cooperation with Cincinnati Univ. Medical Center, OH.
||Pub. in Fundamental and Applied Toxicology 5, p672-678 1985.
|NTIS Title Notes
||Reprint: Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat.
|PUB Date Free Form
||6T; 57Y; 68D
||Not available NTIS