||Application of Pharmacokinetic Models to Predict Target Dose (Chapter 2).
Blancato, J. N. ;
Bishoff, K. B. ;
||Environmental Monitoring Systems Lab., Las Vegas, NV. ;Delaware Univ., Newark.
Risk assessment ;
Public health ;
Health risks ;
Chemical compounds ;
Flow distribution ;
Research and development ;
Environmental monitoring ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The number of new and old chemical compounds to which the human race is exposed has quickly become astronomical. Methods of risk assessment have been slow to develop. Industry, government and academia have had to scrupulously examine the benefits-to-cost ratio of these studies. The limiting factors appear to be the questions of extrapolation and the compatibility of different metabolic processes in different species. The chapter discusses (1) pharmacokinetics, (2) model development, (3) flow-limited assumptions, (4) membrane-limited assumption, (5) micropharmacokinetic physiologic models and their implementation.
||Pub. in Health Risk Assessment, Dermatology: Clinical and Basic Science, Chapter 2, p31-46. Prepared in cooperation with Delaware Univ., Newark.
|NTIS Title Notes
||Reprint: Application of Pharmacokinetic Models to Predict Target Dose (Chapter 2).
||68G; 57Q; 57U; 57S
||PC A03/MF A01