||Insect Virus: Assays for Toxic Effects and Transformation Potential in Mammalian Cells.
Hartig, P. C. ;
Chapman, M. A. ;
Hatch, G. G. ;
Kawanishi., C. Y. ;
||Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
In vitro analysis ;
Autographa californica ;
Viral cell transformation ;
Biological pest control ;
Dose-response relationships ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The increased sensitivity and reproducibility of two new assays developed for inclusion in Subdivision M of the Pesticide Assessment Guidelines are demonstrated. The IRS assay for toxicity and SHE/SA7 transformation assay were utilized together with presently recommended mammalian cell culture tests on a candidate viral pesticide. The results show that the IRS assay was capable of showing the cytotoxicity of the pesticidal agent in more different human cell lines and at lower dosages than the presently prescribed tests. The SHE/SA7 assay had significantly lower spontaneous transformation levels than the Balb/c 3T3 test. (Copyright (c) 1989, American Society for Microbiology.)
||Pub. in Applied and Environmental Microbiology, v55 n8 p1916-1920 1989. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Insect Virus: Assays for Toxic Effects and Transformation Potential in Mammalian Cells.
||57Y; 57P; 57K
||PC A02/MF A01