Full Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Initial Submission: 24-Hour Exposure Clonal Syrian Golden Hamster Embryo (SHE) Cell Transformation Assay using Ortho-Toluidine with Cover Letter dated 04/30/1996.
CORP Author Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1996
Report Number 8EHQ-0596-13643
Stock Number OTS0558517
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Ortho-toluidine ; Chronic toxicity ; Cell transformation ; Mammals ; Hamsters ; In vitro ; CAS No 636-21-5
Library Call Number Additional Info Location Last
NTIS  OTS0558517 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 49p
Abstract A 24 hour exposure SHE cell transformation assay was performed to test the morphological transformation potential of ortho-Toluidine. The assay was performed according to the methodology outlined in the attached protocol. In the 24 hour SHE assay ortho-Toluidine gave significant (p<0.05) morphologicd transformation results, relative to the solvent control, at 4 of 5 tested concentrations. The trend test result for this assay was also significantly positive. According to our established criteria which states that either two positive doses or one positive dose and a positive trend test constitutes a positive SHE cell transformation assay result, ortho-Toluidine is considered positive in the 24 hour exposure SHE cell transformation assay.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 1 May 1996
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A04/MF A04
Document Type NT
Cataloging Source NTIS/MT
Control Number 010500290
Origin NTIS
Type CAT