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OLS Field Name OLS Field Data
Main Title Reduction of Microsomial Phospholipids in Experimental Cardiac Discompensation. (Heart-Lung of Rat Preparation).
Author Panagia, V. ; Minelli, R. ; Zonta., F. ;
CORP Author Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Year Published 1971
Report Number EPA-TR-67-73 ;APTIC-48029;
Stock Number PB-237 730-T
Additional Subjects Cardiovascular diseases ; Lipids ; Ribosomes ; Biochemistry ; Heart ; Pathophysiology ; Etiology ; Mitochondria ; In vitro analysis ; Italy ; Translations ; Experimental data ; Molecular biology
Library Call Number Additional Info Location Last
NTIS  PB-237 730-T Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 15p
Abstract Because previous results had shown that experimental heart failure was not caused by reduction of oxidable substrate and high-energy phosphate content in myocardial tissue, further experiments have been performed in order to see if any alteration in subcellular membranes, which are strictly involved in the excitation-contraction coupling mechanism, could be detected in failing heart. Experimental cardiac failure was realized by imposing a high load on the left ventricle of the rat heart-lung preparation. The determination of mitochondrial and microsomal phospholipid classes has shown: (1) no change in mitochondrial phospholipids and (2) a 20% reduction in phosphatidylcholine, 35% in phosphatidylserine and 34% in sphingomyelin in the microsomal fraction from failed heart.
Supplementary Notes Trans. of il Farmaco (Italy) v26 p1006-1014 Nov 71.
PUB Date Free Form Nov 71
Category Codes 6A; 6E
NTIS Prices PC A02/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 326595750
Origin NTIS
Type CAT