Main Title |
Concept of Activity Profiles of Antimutagens. |
Author |
Waters, M. D. ;
Brady, A. L. ;
Stack, H. F. ;
Brockman, H. E. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences. |
Publisher |
1 Aug 89 |
Year Published |
1989 |
Report Number |
EPA/600/D-90/037; |
Stock Number |
PB90-220781 |
Additional Subjects |
Toxicology ;
Mutagens ;
Bioassay ;
Free radicals ;
Tables(Data) ;
Salmonella typhimurium ;
Reprints ;
Mutagenicity tests ;
Carcinogenesis ;
Carcinogenicity tests ;
Mutagenicity tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-220781 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
The paper will consider the use of short-term bioassays to identify antimutagenic and anticarcinogenic substances and to classify them according to the locus of their protective influence, i.e., intracellular or extracellular, and putative mechanism(s) of action. In the extracellular environment, inhibition of formation or uptake of mutagens and inactivation of promutagenic or mutagenic species are examples of antimutagenic mechanisms. Intracellularly, antimutagenic substances have been described as 'scavengers' of radicals, 'blocking agents' (involving at least 3 different mechanisms), and 'suppressing agents'. Additional intracellular mechanisms include alterations in DNA repair processes and/or modification of the genotoxic response to the mutagen/carcinogen. The presentation format will be based on the genetic activity profile (GAP) methodology developed by the authors. The GAPs of known mutagens/carcinogens will be presented together with newly designed profiles for antimutagens/anticarcinogens according to the classification scheme outlined above. |
Supplementary Notes |
Pub. in Antimutagenesis and Anticarcinogenesis Mechanisms II, p87-104 Jan 90. See also PB90-112806. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Illinois State Univ., Normal. Dept. of Biological Sciences. |
Title Annotations |
Reprint: Concept of Activity Profiles of Antimutagens. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019413350 |
Origin |
NTIS |
Type |
CAT |