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RECORD NUMBER: 45 OF 214

OLS Field Name OLS Field Data
Main Title Chemical Interactions among Chlorohydrocarbon Mixtures Found in Wastewater Effluents.
Author Merrick, B. A. ; Stober, J. A. ; Condie, L. W. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div.
Year Published 1988
Report Number EPA/600/D-88/150;
Stock Number PB88-238456
Additional Subjects Chlorohydrocarbons ; Water pollution ; Chloroform ; Carbon tetrachloride ; Rats ; Pathophysiology ; Chemical reactions ; Toxicity ; Waste water ; Drinking water
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NTIS  PB88-238456 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/29/1988
Collation 22p
Abstract Various chlorohydrocarbons found in industrial waste effluents, including chloroform (CHC13) and carbon tetrachloride (CCl4), can eventually contaminate public drinking water supplies. The present study was designed to evaluate the interaction between orally administered CHCl3 and CCl4 at hepatic and renal toxic threshold doses in male, Sprague Dawley rats. CHCl3 was administered by oral gavage once daily for 3 days Prior to sacrifice at 0, 0.1, 0.5 and 1.0 mmole/kg/day by itself or in combination with CCl4 at 0.1, 0.5 and 1.0 mmole/kg (administered by oral gavage 16 hr prior to sacrifice). The severity and frequency of hepatocellular damage increased in a dose-related manner with CCl4 and to a lesser extent with CHCl3 when they were administered individually. Renal damage was most evident in the highest CHCl3 dose group. Histopathology and serum enzyme data indicated that hepato-toxicity was greater than additive when CCl4 and CHCl3 were given in combination.
PUB Date Free Form Aug 88
Category Codes 68D; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 829120819
Origin NTIS
Type CAT