||Dermal Penetration of ((14)C)Captan in Young and Adult Rats.
Fisher, H. L. ;
Hall, L. L. ;
Sumler, M. R. ;
Shah, P. V. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Skin absorption ;
Carbon 14 ;
In vivo analysis ;
In vitro analysis ;
Tissue distribution ;
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||Dermal penetration of (14C) Captan was determined in young (33 day old) and adult (82 day old) female Fischer 344 rats by an in vivo method and two in vitro methods. Dermal penetration in vivo at 72 hours was about 9% of the dose in both young and adult rats. No significant difference in dermal penetration (in vivo) between young and adult rats was found. Captan was applied at 0.286 micromoles/sq cm. The percentage penetration was found to increase as dosage decreased. Two in vitro methods gave variable dermal penetration values compared to in vivo results. A static system yielded higher dermal penetration values by about two fold compared to in vivo results for both young and adult rats. A flow system yielded higher dermal penetration values in young rats and lower penetration values in adults compared to in vivo results. A physiological pharmacokinetic model was developed having a dual compartment for the treated skin and appeared to describe dermal absorption and disposition reasonably well. Tissue/blood ratios for organs were found to range from 0.35 to 3.4 indicating no large uptake or binding preferences by any organ.
||Pub. in Jnl. of Toxicology and Environmental Health, v36 n3 p251-271 Jul 92. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC., and NSI Technology Services Corp., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Dermal Penetration of ((14)C)Captan in Young and Adult Rats.
||PC A03/MF A01