| Main Title |
Use of the Fungicide Carbendazim as a Model Compound to Determine the Impact of Acute Chemical Exposure during Oocyte Maturation and Fertilization on Pregnancy Outcome in the Hamster. |
| Author |
Perreault, S. D. ;
Jeffay, S. ;
Poss, P. ;
Laskey, J. W. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA-68-02-4450; EPA/600/J-92/261; |
| Stock Number |
PB92-206416 |
| Additional Subjects |
Abortion ;
Fungicides ;
Fertilization ;
Animal pregnancy ;
Hamsters ;
Microtubules ;
Dose-response relationships ;
Meiosis ;
Toxicology ;
Reprints ;
Methylbenzimidazole carbamate
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-206416 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The fungicide MBC is a microtubule poison. The authors hypothesized that microtubule-dependent events occurring in the oocyte during meiotic maturation and fertilization may be sensitive to perturbation by MBC such that exposure to MBC during the critical peri- fertilization period would result in early pregnancy loss. Female hamsters were given a single oral dose of MBC during meiosis I or II. Pregnancy outcome was assessed on day 15. When given during meiosis I, MBC treatment reduced the percentage of pregnant hamsters (at 750 or 1000 mg/kg), and the average litter size (250 to 1000 mg/kg). When given during meiosis II, shortly before and during fertilization, MBC treatment (1000 mg/kg) produced a similar decrease in litter size. The effect disappeared when MBC was administered at a slightly later time, after the microtubule- dependent events of fertilization have occurred. These results demonstrate that a single exposure to a microtubule poison such as MBC at critical times, coincident with microtubule-dependent meiotic events, can result in very early pregnancy loss. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 114, n2 p225-231 Jun 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Use of the Fungicide Carbendazim as a Model Compound to Determine the Impact of Acute Chemical Exposure during Oocyte Maturation and Fertilization on Pregnancy Outcome in the Hamster. |
| Category Codes |
57Y; 57S; 68E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
226924102 |
| Origin |
NTIS |
| Type |
CAT |
