||Comparative Study of the Effects of Inhaled Cadmium Chloride and Cadmium Oxide: Pulmonary Response.
Grose, E. C. ;
Richards, J. H. ;
Jaskot, R. H. ;
Menache, M. G. ;
Graham, J. A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh.
Laboratory animals ;
Air pollution effects ;
Cadmium chloride ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The effect of aerosols of cadmium chloride (CdCl2) and cadmium oxide (CdO) on pulmonary biochemical function were compared. Rats and rabbits were exposed to 0.25, 0.45 or 4.5 mg Cd/cu. m. for 2 hr. Pulmonary toxicity was determined histologically and biochemically. Cadmium chloride and CdO showed a deposition response that was linearly related to the chamber concentration. Both compounds caused multifocal, interstitial pneumonitis 72 hr after exposure, but the CdO lesion was more severe with proliferation of fibrocytic-like cells as well as pneumocytes. Comparing the two Cd compounds at the highest concentration 4.5 mg Cd/cu. m., the biochemical responses in the rat were similar. The majority of the effects occurred 72 hr after exposure with significant increases in: lung weight, lung to body weight ratio, homogenate and supernatant total protein, GSH-reductase, GSH-transferase, and G-6-PDH. However, GSH-peroxidase was inhibited immediately after the CdO exposure.
||Pub. in Jnl. of Toxicology and Environmental Health, v21 p219-232 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and North Carolina State Univ. at Raleigh.
|NTIS Title Notes
||Reprint: Comparative Study of the Effects of Inhaled Cadmium Chloride and Cadmium Oxide: Pulmonary Response.
|PUB Date Free Form
||57Y; 57O; 68A
||PC A03/MF A01