Main Title |
MTBE: Repeated (13-Week) Vapor Inhalation Study in Rats with Neurotoxicity Evaluation and MTBE: Single Exposure Vapor Inhalation Neurotoxicity Study in Rats with Attachments and Letter. |
CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
30 Oct 1989 |
Year Published |
1989 |
Report Number |
FYI-OTS-1189-0689; |
Stock Number |
OTS-0000689-3 |
Additional Subjects |
Rats ;
Neurotoxicity ;
Exposure ;
Body weight ;
Food consumption ;
Nervous system ;
Motor activity ;
Vapor inhalation ;
Methyl tertiary butyl ether ;
Fischer 344 rats ;
Hematologic analysis ;
Serum chemistry
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000689-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
820p |
Abstract |
Four groups, each consisting of 25 male and 25 female Fischer 344 rats, were exposed 6 hours per day, 5 days per week, for 13 weeks to vapor of methyl tertiary butyl ether (MTBE) at target concentrations of 8000, 400, 800, or 0 (control) ppm. The 8000 ppm concentration was chosen as the high exposure level due to the explosive nature of MTBE. The Environmental Protection Agency in the Section 4 Consent Order agreed to limit the high exposure level to 502 of the lower explosion limit for MTBE (i.e., 8000 ppm). Monitors for toxicity were as follows: daily clinical observations; function observational batted on study weeks 1, 2, 4, 8, and 13. Motor activity on study weeks 4, 8, and 13 body weights; food consumption; hematological analyses; serum chemistry including selected adrenal hormonal analyses: organ weights; and ophthalmic, gross pathologic, and microscopic evaluations. Detailed microscopic evaluations were performed on the nervous system of selected rats (6/sex/group) following perfusion fixation of tissues. |
Supplementary Notes |
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Availability Notes |
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Category Codes |
57 |
NTIS Prices |
PC A99/MF E08 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019103410 |
Origin |
NTIS |
Type |
CAT |