| Main Title |
Hydroquinone: A Developmental Toxicity Study in Rats with Cover Letter and EPA Acknowledgement Letter. |
| CORP Author |
Eastman Kodak Co., Rochester, NY. Health and Environment Labs.;Chemical Manufacturers Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Sep 1985 |
| Year Published |
1985 |
| Report Number |
FYI-AX-1285-0468; |
| Stock Number |
OTS-0000468-0 |
| Additional Subjects |
Rats ;
Hydroquinone ;
Toxicity ;
Body weight ;
Feed consumption ;
Malformations ;
Toxicity studies
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000468-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
94p |
| Abstract |
The objective of this study was to determine the development toxicity potential of hydroquinone in the rat. Pregnant Crl: COBS 'CD' (SD) BR rats were given 0, 30, 100 or 300 mg/kg of hydroquinone by gavage on the 6th through the 15th days of gestation and fetuses were examined near term. Maternal toxicity was seen as a slight but statistically significant reduction in body weight gain and feed consumption during the treatment period in the dams given 300 mg/kg hydroquinone. A few spontaneous malformations were seen, but no compound-related teratogenic effects were found. Minor soft tissues and skeletal changes, variations commonly found in developmental toxicity studies, did not occur at a significantly higher incidence in the treated groups than in the control group. Reproductive indices of the hydroquinone dams were comparable to the controls. A reduction in mean fetal body weight seen at the high dose level (300 mg/kg) correlated with the reduced body weight seen in the dams at this dose level. In conclusion, doses as high as 300 mg/kg hydroquinone did not produce teratogenic effects, other embryotoxicity, or fetotoxicity in the rat. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A06/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001890 |
| Origin |
NTIS |
| Type |
CAT |
