Main Title |
Ninety-Day Study of Terephthalic Acid-Induced Urolithiasis and Reproductive Performance in Wistar and CD Rats. |
Author |
Ledoux, T. A. ;
Reel, J. R. ;
|
CORP Author |
Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
Jan 1982 |
Year Published |
1982 |
Report Number |
FYI-OTS-0482-0190-IN ;RTI/1937/00-04F; |
Stock Number |
OTS-0000190-0 |
Additional Subjects |
Terephthalic acid ;
Reproduction ;
Wistar rats ;
Rats ;
Experiments ;
Food consumption ;
Body weight ;
Toxicity ;
Induced urolithiasis ;
CD rats
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000190-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Dose-related decreases in food consumption, body weight and weight gain were found in adult male and female Wistar and CD rats during 90 days of feeding of 0, 0.03, 0.125, 0.5, 2.0 or 5% terephthalic acid (TPA) in the diet. Statistically significant decreases in these parameters were confined mainly to the two highest dietary levels of TPA. TPA was more toxic to CD than Wistar rats in that body weights were also significantly lower at the 2% TPA dietary level in both male and female CD rats at 4 and 13 weeks. Five unscheduled deaths occurred between 4 and 13 weeks in animals ingesting 5% dietary levels of TPA. Three of these five deaths involved CD females, which by this and the parameters mentioned above, exhibited the greatest sensitivity to the toxic effects of TPA. No bladder stones were observed in the five dead animals at necropsy. However, trichobezoars (hairballs) were found in the gastrointestinal tract of one CD female. Trichobezoars also were noted in 4 of 7 parental rats (one Wistar male and female and two CD females) that died during the one-generation study. Diarrhea was observed in some of the rats ingesting high concentrations of dietary TPA. A one-generation reproduction study was conducted in tandem with the 90-day feeding study. |
Supplementary Notes |
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Availability Notes |
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Category Codes |
57 |
NTIS Prices |
PC A02/MF$25.00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
005101280 |
Origin |
NTIS |
Type |
CAT |