Main Title |
Subacute and Subchronic Toxicity of Ethylene Glycol Administered in Drinking Water to Sprague-Dawley Rats. |
Author |
Robinson, M. ;
Pond, C. L. ;
Laurie, R. D. ;
Bercz, J. P. ;
Henningsen., G. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., West Chester, OH. ;Procter and Gamble Co., Cincinnati, OH. ;Harry G. Armstrong Aerospace Medical Research Lab., Wright-Patterson AFB, OH. ;Army Dugway Proving Ground, UT. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/090; |
Stock Number |
PB90-245374 |
Additional Subjects |
Toxicity ;
Ethylene glycol ;
Pathology ;
Potable water ;
Body weight ;
Water consumption ;
Food consumption ;
Blood chemical analysis ;
Kidney ;
Reprints ;
Sprague-Dawley rats ;
Dose-response relationships ;
Organ weight ;
Sex factors
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-245374 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
30p |
Abstract |
Subacute (10-day) and subchronic (90-day) toxicity studies of ethylene glycol (EG) were conducted in male and female Sprague-Dawley rats to provide the U.S. Environmental Protection Agency's (EPA) Office of Drinking Water with toxicity data for final preparation of a Health Advisory for the chemical. Ethylene glycol was administered in drinking water at concentrations of 0.5, 1.0, 2.0, and 4.0% for both sexes in the 10-day study. Based on a projected consumption rate of 100 ml/kg/day, the respective doses on a mg/kg/day basis would be 554, 1108, 2216, and 4432. These dose levels were also used in the 90-day study for females, but dose levels for the males in the 90-day study were 0.25, 0.5, 1.0, and 2.0% (227, 554, 1108, and 2216 mg/kg/day). Hemoglobin, hematocrit, erythrocytes, and leukocytes were all significantly decreased in female rats, receiving 4% EG for 10 days. The most significant histopathological findings, seen predominantly in males, were kidney lesions. |
Supplementary Notes |
Pub. in Drug and Chemical Toxicology, v13 n1 p43-70 Mar 90. Prepared in cooperation with Pathology Associates, Inc., West Chester, OH., Procter and Gamble Co., Cincinnati, OH., Harry G. Armstrong Aerospace Medical Research Lab., Wright-Patterson AFB, OH., and Army Dugway Proving Ground, UT. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Subacute and Subchronic Toxicity of Ethylene Glycol Administered in Drinking Water to Sprague-Dawley Rats. |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
024227935 |
Origin |
NTIS |
Type |
CAT |