||Evaluation of the Immunotoxicity of Low Level PCB (Polychlorinated Biphenyl) Exposure in the Rat.
Smialowicz, R. J. ;
Andrews, J. E. ;
Riddle, M. M. ;
Rogers, R. R. ;
Luebke, R. W. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Body weight ;
Polychlorinated biphenyl compounds ;
Immunologic cytotoxicity ;
Dose-response relationships ;
Organ weight ;
Natural killer cells ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Weanling male Fischer 344 rats were exposed daily by gastric intubation for up to 15 weeks to the polychlorinated biphenyl (PCB) Aroclor 1254 at 0.1, 1, 10, or 25 mg/kg body weight. At 5, 10 and 15 weeks groups of rats were killed and immune functions were evaluated. The immune parameters examined included the following: body and lymphoid organ weights, mitogen stimulated lymphoproliferative (LP) responses, natural killer (NK) cell activity, mixed lymphocyte reaction (MLR), and cytotoxic T lymphocyte (CTL) response. After 10 and 15 weeks of dosing body weights were reduced in rats receiving 25 mg/kg PCB while thymus weights were decreased in rats receiving 10 and 25 mg/kg. NK cell activity was reduced in rats dosed for 15 weeks at 10 and 25 mg/kg. The LP response to phytohemagglutinin was enhanced in rats dosed for 15 weeks at 25 mg/kg PCB. Exposure of rats to PCB did not affect the MLR or CTL responses. Other groups of rats were exposed to cyclophosphamide (CY) and served as positive controls for the immune assays employed. CY induced alterations in all of the immune parameters measured, indicating that this is a sensitive battery of immune function tests which is capable of detecting immune alterations in the rat. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland, Ltd.)
||Pub. in Toxicology, v56 p197-211 1989.
|NTIS Title Notes
||Reprint: Evaluation of the Immunotoxicity of Low Level PCB (Polychlorinated Biphenyl) Exposure in the Rat.
||PC A03/MF A01