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RECORD NUMBER: 22 OF 37

OLS Field Name OLS Field Data
Main Title Differences in Inflammatory Responses to Exposures of Concentrated Ambient Particles in Susceptible Volunteers.
Author M. A. Riedl ; W. S. Linn ; K. W. Clark ; D. Diaz-Sanchez
CORP Author California Univ., Los Angeles.; California State Air Resources Board, Sacramento.; California Environmental Protection Agency, Sacramento.
Year Published 2010
Report Number CARBRA-05-341
Stock Number PB2010-110811
Additional Subjects Particulates ; Air pollution ; Human health ; Environmental exposure ; Health effects ; Response ; Cardiopulmonary ; Biomarkers ; Respiratory system ; Tables(Data) ; Asthma ; Physiology ; Inflammation ; Monitoring ; Regulations ; Symptoms
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NTIS  PB2010-110811 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/21/2011
Collation 84p
Abstract Respirable particulate matter (PM) is associated with harmful cardiopulmonary effects in humans. To test the hypothesis that individuals with certain susceptibility factors have heightened inflammatory and airway responses to PM exposure, a single-blind randomized dose crossover human study of controlled exposure to filtered air (FA), and concentrated ambient particles (CAPS) was conducted. We enrolled 10 mild- moderate asthmatic GSTMI null subjects, 10 mild- moderate asthmatic GSTMI present subjects and 10 healthy GSTMI present subjects to determine the short-term effects of CAPS exposure in individuals likely to be at risk for adverse effects. Outcome measures included symptom scores, physiologic measures (vital signs, spirometry, exhaled nitric oxide, heart rate variability) as well as serum, sputum, and nasal lavage samples for inflammatory biomarkers.
Supplementary Notes Sponsored by California State Air Resources Board, Sacramento. and California Environmental Protection Agency, Sacramento.
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PUB Date Free Form Apr 2010
Category Codes 68A; 68G; 57E
NTIS Prices PC A06/MF A06
Document Type NT
Medium Final rept
Cataloging Source NTIS/MT
Control Number 128600730
Origin NTIS
Type CAT