Main Title |
Acute Effects and Long-Term Sequelae of 1,3-Dinitrobenzene on Male Reproduction in the Rat. 1. Sperm Quality, Quantity, and Fertilizing Ability. |
Author |
Linder, R. E. ;
Hess, R. A. ;
Perreault, S. D. ;
Strader, L. F. ;
Barbee, R. R. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/376; |
Stock Number |
PB90-103078 |
Additional Subjects |
Toxicology ;
Fertility ;
Reproduction(Biology) ;
Males ;
Rats ;
Graphs(Charts) ;
Reprints ;
Spermatozoa ;
Biological effects ;
Dinitrobenzenes ;
Organ weight
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-103078 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Groups of eight adult male rats were given a single oral dose of 0 or 48 mg/kg of 1,3-dinitrobenzene and sacrificed at 1, 2, 4, 8, 16, 24, 32, 72, and 175 days posttreatment. The groups killed at 175 days were bred to untreated females during weeks 3, 4, 6, 9, 13, and 24. Decreased testis weight and testicular sperm numbers were observed by day 4; decreased cauda sperm reserves and epididymis weight occurred by day 8 and day 16, respectively. Reduced numbers of motile spermatozoa and abnormal sperm morphology were seen in spermatozoa from the cauda epididymidis by day 16. Fertilizing ability, as indicated by the presence of two pronuclei and a sperm tail in eggs flushed from the oviducts of inseminated females, was slightly reduced by week 4 and declined to zero by week 6. Group means for reproductive organ weights, sperm production, and sperm reserves failed to return to control levels although some individual animals approaching full recovery. Normal fertilizing ability was restored in most animals by week 13, but two of seven remained infertile. |
Supplementary Notes |
Pub. in Jnl. of Andrology, v9 n5 p317-326 Sep/Oct 88. See also PB90-103086. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Acute Effects and Long-Term Sequelae of 1,3-Dinitrobenzene on Male Reproduction in the Rat. 1. Sperm Quality, Quantity, and Fertilizing Ability. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
935215909 |
Origin |
NTIS |
Type |
CAT |