Main Title |
Ultrastructure of the Paraquat Lung Lesion in the Rat. |
Author |
Kimbrough, Renate D. ;
Linder., Ralph E. ;
|
CORP Author |
Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs. |
Year Published |
1972 |
Stock Number |
PB-279 722 |
Additional Subjects |
Herbicides ;
Pesticides ;
Toxicology ;
Dosage ;
Ingestion(Biology) ;
Bioassay ;
Rats ;
Diet ;
Laboratory animals ;
Experimental data ;
Lung ;
Histology ;
Pathology ;
Reprints ;
Paraquat ;
Bipyridinium compounds ;
Acetic acid/mercaptophenyl ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-279 722 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Adult female Sherman strain rats were fed 500 ppm paraquat (1,1-dimethyl-4,4-bipyridylium dichloride) in their diet. Four poisoned as well as three control rats were sacrificed 1, 3, 5, 7 and 11 wk after onset of exposure. Two well-developed paraquat lung lesions were encountered. The alveoli of these lesions contained a very prominent amorphous material which was highly osmiophilic when examined with the electron microscope. It consisted of concentrically arranged whorls which were surrounded by or next to less electrondense lattice-like material. Additional ultrastructural findings in those and other lungs consisted of edematous and vacuolated membranous pneumocytes (type I) as well as endothelial cells. The granular pneumocytes were increased in 3 of 20 lungs of exposed animals. |
Supplementary Notes |
Pub. in Environmental Research 6, p265-273 1973. |
Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 9, PB-279 718. |
Title Annotations |
Reprint: The Ultrastructure of the Paraquat Lung Lesion in the Rat, |
PUB Date Free Form |
18 Aug 72 |
Category Codes |
6T; 57Y; 68G; 68E |
NTIS Prices |
(Order as PB-279 718, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323738880 |
Origin |
NTIS |
Type |
CAT |