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RECORD NUMBER: 689 OF 1243

OLS Field Name OLS Field Data
Main Title Methemoglobin Levels in Beagle Dogs Following Oral Administration of P-phenylenediamine.
CORP Author Clairol Research Laboratories.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8036147
Stock Number OTS0506089
Additional Subjects Toxicology ; Health effects ; P-phenylenediamine ; Biochemistry ; Mammals ; Dogs ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 106-50-3
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NTIS  OTS0506089 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 11p
Abstract Para-Phenylenediamine (CAS No. 106-50-3) was evaluated as cause for methemoglobinuria in sets of 2 each beagle dogs fed single gavage doses of 1.0, 3.0 and 10.0 mg/kg bodyweight. All dogs exhibited lacrimation, while 10.0 mg/kg dosed dogs showed red and swollen eyes persisting in one dog at 24-hour post-gavage observation. Slight redness was also noted in the eyes of 3.0 mg/kg dogs, but all such signs were resolved by 24 hours after treatment. Cyanosis and anoxia were not noted in any dog of any treatment level. Likewise, methemoglobinemia was not induced at levels producing pharmacotoxic effects in beagle dogs.
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PUB Date Free Form 2000
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Cataloging Source NTIS/MT
Control Number 028801150
Origin NTIS
Type CAT