||Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat.
Schut, H. A. J. ;
Daniel, F. B. ;
Schenck, K. M. ;
Loeb, T. R. ;
Stoner, G. D. ;
||Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Research Triangle Park, NC.
Environmental surveys ;
Malignant neoplasms ;
Deoxyribonucleic acids ;
Laboratory animals ;
Aromatic compounds ;
Industrial hygiene ;
Chemical bonds ;
Occupational safety and health ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||It is concluded that bladder explants of the human, dog, monkey, hamster, and rat metabolize AAF mainly to ring-hydroxylated products, but also form small amounts of the proximate carcinogenic metabolite N-hydroxy-AAF. Neither the overall binding of AAF to bladder DNA, nor the formation of specific AAF-DNA adducts is correlated with the relative susceptibilities of these five species to aromatic amine-induced urinary bladder carcinogenesis.
||Pub. in Carcinogenesis, v5 n10 p1287-1292 1984.
|NTIS Title Notes
||Reprint: Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat.
|PUB Date Free Form
||6A; 6T; 7D; 68G; 57B; 57Y; 99F; 41I; 94D
||Not available NTIS