||Acrylamide: a Two-year Drinking Water Chronic Toxicity-oncogenicity Study in Fischer 344 Rats Final Report Sponsored by Amer Cyanamid, dow Chem Usa, Nalco Chem.
||Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Chronic Toxicity ;
Combined Chronic Toxicity/carcinogenicity ;
Toxic substances ;
Laboratory animals ;
CAS No 79-06-1
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Acrylamide was tested for chronic toxicity and oncogenicity in Fischer 344 rats (90/sex/dose level) fed nominal doses of 0, 0.01, 0.1, 0.5, or 2.0 mg/kg bw/day in the drinking water for 2 years. In groups given 2.0 mg/kg/day, there was significantly increased mortality (beginning about the 21st month) and degeneration of the peripheral nerves. In females given 2.0 mg/kg/day, tibial nerve degeneration was observed. Other parameters of food and water consumption, clinical chemistry, organ weights, and organ/body weight ratios were not consistently affected by the treatment. A significantly increased tumor incidence at the 2.0 mg/kg/day dose level was reported for the following sites: females; mammary gland (benign and malignant), pituitary gland, central nervous system (malignant), clitoral gland (benign), uterus (malignant), and the oral cavity (benign); males and females; the thyroid gland (malignant and benign). The incidence of scrotal mesothelioma (malignant) was also significantly increased in male rats given 0.5 mg/kg/day.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at firstname.lastname@example.org. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
|PUB Date Free Form
||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04