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OLS Field Name OLS Field Data
Main Title Myelin Basic Protein-mRNA Used to Monitor Trimethyltin Neurotoxicity in Rats.
Author Veronesi, B. ; Pringle, J. ; Mezei., C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/159;
Stock Number PB91-231274
Additional Subjects Encephalitogenic basic proteins ; Messenger RNA ; Trimethyltin ; Toxicity ; Brain ; Histology ; RNA probes ; Nerve cells ; Nucleic acid hybridization ; Northern blotting ; Hippocampus ; Pathology ; Biochemistry ; Reprints ;
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NTIS  PB91-231274 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 11p
Abstract Trimethyltin (TMT) is an alkyltin that targets neurons of the limbic system. A gene probe (i.e., mRNA) for myelin basic protein (MBP), a major component of central nervous system myelin, was used to monitor this toxic neuropathy in Sprague-Dawley rats. Animals were administered a single intraperitoneal injection of TMT-hydroxide at a neuropathic (8.0 mg/kg/body wt) or nonneuropathic (0.8 mg/kg/body wt) dose and sampled at 1, 3, or 7 days postexposure to correlate the progression of hippocampal neuropathology with probe (i.e., MBP-mRNA) levels. Microscopic examination of the brain showed only moderate but progressive damage over the 7-day postexposure period in animals treated with the neuropathic dose. Neuronal loss was first observed in the dendate gyrus and CA4 at 1 day postexposure, and progressed to the CA3c sector at 3 and 7 days postexposure. Elsewhere in the brain, minimal involvement of the entorhinal cortex neurons occurred 3 days postexposure and intensified by 7 days. No histological damage was seen at the nonneuropathic (0.8 mg/kg) dose. (Copyright (c) 1991 by Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v108 n3 p428-435 May 91. Portions of this document are not fully legible. Prepared in cooperation with Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry.
NTIS Title Notes Journal article.
Title Annotations Reprint: Myelin Basic Protein-mRNA Used to Monitor Trimethyltin Neurotoxicity in Rats.
Category Codes 57Y; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 128229521
Origin NTIS
Type CAT