Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 507 OF 1241

OLS Field Name OLS Field Data
Main Title Gas Chromatographic Assay Pcbtf and Modified 90-day Gavage and Reproduction Study in Rats - Part Ii.
CORP Author Hooker Chemical Corp., Burlington, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8152022
Stock Number OTS0508148
Additional Subjects Toxicology ; Health effects ; 4-chlorobenzotrifluoride ; Pharmaco Kinetics ; Mammals ; Rats ; Oral ; Implant ; Reproduction/fertility Effects ; Combined Teratogenicity/reproductive Effects ; Gavage ; Biochemistry ; Subchronic Toxicity ; Toxic substances ; Laboratory animals ; CAS No 98-56-6
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS0508148 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 376p
Abstract In a two-generation reproduction study, male and female Sprague Dawley rats (F0) (20/sex/group) were orally exposed to 4-(trifluoromethyl) chlorobenzene (TFCB) in corn oil vehicle by gavage at dosage levels of 0, 5, 15 or 45 mg/kg/day for 4 weeks prior to mating one-to-one with animals of the same group, and continuing through one reproduction period until F1 litters had been weaned. Randomly selected F1 pups (20/sex/group) were orally exposed to TFCB by gavage at the same concentration as their parents for 90 days and were then sacrificed. Significant differences between treated and control F0 rats were observed in the following: decreased and/or increased weight gain (high- and mid-dose animals). Significant differences between treated and control F1 rats were observed in the following: weight gain (increased for all treated male groups, decreased for high-dose females), decreased monocytes (females at low-dose), increased serum glutamic-pyruvic transaminase (mid-dose females), increased mean pups/litter (combined sexes of pups for low- and mid-dose groups, female pups of mid-dose group), increased percentage surviving pups and pup weights (all treated groups), decreased erythrocyte counts (low-dose females), decreased mean corpuscular hemoglobin (all treated male groups and high-dose females), increased mean corpuscular volume (high-dose females), and an increase in pathology of the lung including bronchopneumonia, adenomous hyperplasia, and inflammatory cell infiltrates (all treated groups). No significant differences between treated and control F0 rats were observed in the following: mortalities, urinalysis, and dam weights. No significant differences between treated and control F1 rats were observed in the following: mortalities, clinical chemistry values, urinalysis, and absolute or relative organ weights.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 2000
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A18/MF A18
Document Type NT
Cataloging Source NTIS/MT
Control Number 028801280
Origin NTIS
Type CAT