Main Title |
Initial Submission: Determination of Material Toxicity & Fetal Toxicity of Benzene in Rats Following Oral Exposure (Final Report) with Cover Letter (Sanitized). |
CORP Author |
Exxon Biomedical Sciences Inc; Exxon Chemical Co., Baton Rouge, LA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
88-920001029S |
Stock Number |
OTS0536017 |
Additional Subjects |
Toxicology ;
Health effects ;
Benzene ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 71-43-2
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0536017 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
57p |
Abstract |
Benzene (CAS No. 71-43-2) was evaluated for developmental toxicity. The test material was administered by oral gavage to pregnant female Sprague-Dawley rats from day 6-15 of gestation at dose levels of 0, 50, 250, 500, or 1000 mg/kg. Body weight and food consumption were measured and physical examinations were performed during gestation. Mated females that survived until the 20th day of gestation were sacrificed and gross necropsies were performed. Necropsy observations were unremarkable. Alopecia was observed on hindquarters, lateral lumbar areas, abdominal inguinal, ventral thoracic and cervical areas in all treatment groups with the effect being significantly different than controls at the 1000 mg/kg group. Maternal weight was significantly reduced in the 500 mg/kg group and above. Following the treatment period, the treated rats gained more weight than controls. Maternal food consumption was significantly reduced at the 250 mg/kg level and above. No statistically significant differences were found among treated groups and controls with respect to pregnancy rate, numbers of live fetuses, resorption implantations, corpora lutea, fetuses per implant, or resorptions per implant. There were no dead fetuses, and no external malformations observed. Live fetal body weight of male and female fetuses in the 500 mg/kg group and above were significantly lower than controls. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Exxon Chemical Co., Baton Rouge, LA. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A05/MF A05 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028803470 |
Origin |
NTIS |
Type |
CAT |