| Main Title |
Investigation of the Chemistry of TDI in Biological Materials, with Cover Letter dated 12/03/1998. |
| CORP Author |
Carnegie-Mellon Univ., Pittsburgh, PA.; International Isocyanate Inst.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Stock Number |
OTS0573868 |
| Additional Subjects |
Toxicology ;
Health effects ;
Benzene 2 ;
4 diisocyanate-1-methyl ;
2 ;
4-toluene di ;
Environmental fate ;
CAS No 584-84-9 ;
CAS No 26471-62-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573868 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
The objective of this study was to investigate the fate of TDI in biological matrices due to its chemical reactivity. The chemistry and biochemistry of isocyanate compounds have been reviewed (Brown, 1986; Brown and Kennedy, 1989). However, as yet, a systematic investigation is not available on the quantitative, qualitative and kinetic aspects of the reactivity of these compounds in biological matrices such as aqueous buffer solutions, protein model systems, blood, plasma, urine and stomach contents. A limited study was performed to analyze the in vitro reactivity of the 2,6 isomer of TDrin fluids such as stomach contents and sera (Jeffcoat, 1985). In both fluids, the half-life of the 2,6 TDI was 2 minutes or less and the reactivity was dependent on the delivering solvent. This data has been extended through a systematic investigation of each of the individual isomers of TDI and of the commercial 80/20 2,4/2,6-TDI isomer mixture. It is also important to address not only the loss of reactive isocyanate but also the fate of the reactive compound. Detailed knowledge of the specificity and kinetics of the reactivity of these compounds under aqueous conditions will help to define the behavior of TDI in animal and man. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
9 Dec 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028701280 |
| Origin |
NTIS |
| Type |
CAT |
