Main Title |
Effect of Benomyl on Reproduction in the Male Rat. |
Author |
Carter, Susan D. ;
Laskey, John W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1981 |
Report Number |
EPA-600/J-81-258; |
Stock Number |
PB82-249293 |
Additional Subjects |
Reproduction(Biology) ;
Carbamates ;
Fungicide ;
Physiological effects ;
Males ;
Rats ;
Laboratory animals ;
Ingestion(Biology) ;
Concentration(Composition) ;
Histology ;
Reprints ;
Benomyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-249293 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Adult Sprague-Dawley male rats (65 days of age) received 10 daily treatments of 0, 200 or 400 mg benomyl/kg/day by gavage. Body weight, tissue weights, total epididymal sperm counts and sperm concentration from the vas deferens were measured 14 days after the last treatment. Testicular histology was evaluated in the 0 and 400 mg/kg/day groups. Significant findings included 35-48% depressions in the total epididymal sperm counts and in the vas deferens sperm concentrations in adult animals treated with 200 or 400 mg/kg/day. Histological evaluations of testicular sections from 6 adult animals in the 400 mg/kg/day group indicated a slight to moderately severe hypospermatocytogenesis in 2 animals and a slight to severe generalized hypospermatogenesis in 2 animals. Caudal epididymis weights were significantly (P less than 0.05) depressed with benomyl treatment. No treatment effects were found in body weight, liver, kidney, tests, or seminal vesicle weights. |
Supplementary Notes |
Pub. in Toxicology Letters 11, p87-94 1982. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effect of Benomyl on Reproduction in the Male Rat. |
PUB Date Free Form |
4 Nov 81 |
Category Codes |
6T; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323822217 |
Origin |
NTIS |
Type |
CAT |