| Main Title |
Correlation of Carcinogenic Potency with Mouse-Skin (32)P-Postlabeling and Muta-(R)Mouse lac Z(-)Mutation Data for DMBA and Its K-Region Sulphur Isostere: Comparison with Activities Observed in Standard Genotoxicity Assays. |
| Author |
Ashby, J. ;
Brusick, D. ;
Myhr, B. C. ;
Jones, N. J. ;
Parry, J. M. ;
|
| CORP Author |
ZENECA Central Toxicology Lab., Cheshire (England). ;University Coll. of Swansea (Wales). School of Biological Sciences. ;Pittsburgh Univ., PA. Graduate School of Public Health. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pittsburgh Univ., PA. Graduate School of Public Health.;Environmental Protection Agency, Research Triangle Park, NC. Carcinogenesis and Metabo |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA-68-02-4456; EPA/600/J-94/062; |
| Stock Number |
PB94-143732 |
| Additional Subjects |
Carcinogens ;
Skin diseases ;
Toxicity ;
Mice ;
Polyaromatic hydrocarbons ;
Assaying ;
Salmonella ;
Mutations ;
DNA ;
Risk assessment ;
Genetics ;
Artificial intelligence ;
Expert systems ;
In vitro analysis ;
In vivo analysis ;
Reprints ;
S-DMBA(6 11-Dimethylbenzo(b)naphtho(2 3-d)thiopene) ;
DMBA(7 12-Dimethylbenz(a)anthracene) ;
MULTICASE
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-143732 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) have been compared with those of its weakly carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo(b)naphtho-(2,3-d)thiophene (S-DMBA). The only datasets that correlated with the relative carcinogenicity of these agents to the skin were those conducted using topically exposed mouse skin. Thus, both chemicals induced lacZ(-) mutations in the skin of lacZ(+) transgenic mice, and both produced DNA adducts on mouse-skin DNA as assessed using the (sup 32) P-postlabeling technique. The molecular geometry of DMBA and S-DMBA are compared, and divergent CASE predictions of activity in the Salmonella assay and skin-painting bioassay are discussed. (Copyright (c) 1993 Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Mutation Research 292, n1 p25-40 Aug 93. Prepared in cooperation with University Coll. of Swansea (Wales). School of Biological Sciences, Pittsburgh Univ., PA. Graduate School of Public Health, Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Pittsburgh Univ., PA. Graduate School of Public Health. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Correlation of Carcinogenic Potency with Mouse-Skin (32)P-Postlabeling and Muta-(R)Mouse lac Z(-)Mutation Data for DMBA and Its K-Region Sulphur Isostere: Comparison with Activities Observed in Standard Genotoxicity Assays. |
| Category Codes |
68G; 57F; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
410526186 |
| Origin |
NTIS |
| Type |
CAT |
