||Morphological Transforming Activity and Metabolism of Cyclopenta-Fused Isomers of Benz(a)anthracene Mammalian Cells.
Mohapatra, N. ;
MacNair, P. ;
Bryant, B. J. ;
Ellis, S. ;
Rudo, K. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Cyclopenta fused isomers
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Cyclopenta-polycyclic aromatic hydrocarbons are a unique class of environmental PAH which contain an unsaturated five-membered ring available for metabolic alteration and metabolic activation. Previous studies with four isomeric cyclopenta-derivatives of benz(a)anthracene: benz(e)aceanthrylene, benz(j)aceanthrylene, benz(l)aceanthrylene, and benz(k)acephenanthrylene indicated that these PAH were mutagenic to Salmonella typhimurium and Chinese hamster V79 cells. In the study, these four isomeric cyclopenta-derivatives of benz(a)anthracene were examined for their ability to morphologically transform C3H10T1/2CL8 mouse embryo fibroblasts. All of the PAH studied except benz(k)acephenanthrylene transformed C3H10T1/2CL8 cells to both type II and type III foci in a concentration-dependent fashion. Benz(j)aceanthrylene was the most active, equivalent in activity to benzo(a)pyrene on a molar basis, in producing dishes of cells with transformed foci (94% at 1.0 micrograms/ml). Benz(e)aceanthrylene, and benz(l)aceanthrylene produced 58% and 85% of the dishes with foci respectively at 10 micrograms/ml.
||Pub. in Mutation Research, v188 p323-334 1987. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Morphological Transforming Activity and Metabolism of Cyclopenta-Fused Isomers of Benz(a)anthracene Mammalian Cells.
|PUB Date Free Form
||PC A03/MF A01