Main Title |
Morphological Transforming Activity and Metabolism of Cyclopenta-Fused Isomers of Benz(a)anthracene Mammalian Cells. |
Author |
Mohapatra, N. ;
MacNair, P. ;
Bryant, B. J. ;
Ellis, S. ;
Rudo, K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/171; |
Stock Number |
PB88-160676 |
Additional Subjects |
Morphology ;
Metabolism ;
Cells(Biology) ;
Mammals ;
Reprints ;
Benz(a)anthracene ;
Cyclopenta fused isomers
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-160676 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Cyclopenta-polycyclic aromatic hydrocarbons are a unique class of environmental PAH which contain an unsaturated five-membered ring available for metabolic alteration and metabolic activation. Previous studies with four isomeric cyclopenta-derivatives of benz(a)anthracene: benz(e)aceanthrylene, benz(j)aceanthrylene, benz(l)aceanthrylene, and benz(k)acephenanthrylene indicated that these PAH were mutagenic to Salmonella typhimurium and Chinese hamster V79 cells. In the study, these four isomeric cyclopenta-derivatives of benz(a)anthracene were examined for their ability to morphologically transform C3H10T1/2CL8 mouse embryo fibroblasts. All of the PAH studied except benz(k)acephenanthrylene transformed C3H10T1/2CL8 cells to both type II and type III foci in a concentration-dependent fashion. Benz(j)aceanthrylene was the most active, equivalent in activity to benzo(a)pyrene on a molar basis, in producing dishes of cells with transformed foci (94% at 1.0 micrograms/ml). Benz(e)aceanthrylene, and benz(l)aceanthrylene produced 58% and 85% of the dishes with foci respectively at 10 micrograms/ml. |
Supplementary Notes |
Pub. in Mutation Research, v188 p323-334 1987. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Morphological Transforming Activity and Metabolism of Cyclopenta-Fused Isomers of Benz(a)anthracene Mammalian Cells. |
PUB Date Free Form |
c1987 |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
809821029 |
Origin |
NTIS |
Type |
CAT |