| Main Title |
Structure-Toxicity Relationships for Industrial Chemicals Causing Type(II) Narcosis Syndrome. |
| CORP Author |
Environmental Research Lab.-Duluth, MN. |
| Year Published |
1987 |
| Report Number |
EPA/600/D-87/286; |
| Stock Number |
PB88-106992 |
| Additional Subjects |
Narcosis ;
Organic compounds ;
Toxicity ;
Minnows ;
Phenols ;
Anilines ;
Hydrogen bonds ;
Models ;
Lethality
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-106992 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Several structure-activity relationships have been published for estimating the lethality of nonpolar nonelectrolytes to fish. The vast majority of non-reactive industrial chemicals produce toxicity symptoms consistent with narcosis. However, researchers have found that many chemicals which appear to produce narcosis, are substantially more toxic than the published structure-toxicity relationship predicts. Researchers observed that these chemicals are more polar and often have acidic hydrogen bond donor functional groups. The data are consistent with the 'polar' narcotic class proposed by Ferguson five decades ago. The structure-toxicity relationship for polar narcotics (n=39; r2 = 0.90) with fathead minnows (Pimephales promelas) is: log LC50 = -0.65 (+ or - 0.07) log P-2.29 (+ or - 0.22). The paper presents the data for the relationship and discusses the structural requirements for the toxicity syndrome. |
| Supplementary Notes |
Pub. in QSAR in Environmental Toxicology-II, p385-391 1987. |
| PUB Date Free Form |
1987 |
| Category Codes |
68G; 57Y; 57H |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
735121194 |
| Origin |
NTIS |
| Type |
CAT |
