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OLS Field Name OLS Field Data
Main Title Mode of action of cyclodiene insecticides /
Author Crowder, Larry A.
CORP Author Arizona Univ., Tucson. Dept. of Entomology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1976
Report Number EPA/600-1-76-008; EPA-R-800384; PB251670
Stock Number PB-251 670
OCLC Number 07762770
Subjects Insecticides. ; Amidines. ; Toxaphene.
Additional Subjects Insecticides ; Toxicology ; Pesticides ; Chlorine aliphatic compounds ; Terpenes ; Chlorohydrocarbons ; Halohydrocarbons ; Nervous system ; Metabolism ; Excretion ; Rats ; Insects ; Laboratory animals ; Experimental data ; Physiological effects ; Toxaphene
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA-600-1-76-008 Headquarters Library/Washington,DC 01/27/2014
EJBD  EPA 600-1-76-008 c.1 Headquarters Library/Washington,DC 02/27/2014
EKAM  SB951.5.C7x 1976 Region 4 Library/Atlanta,GA 05/10/1997
ELBD  EPA 600-1-76-008 AWBERC Library/Cincinnati,OH 08/26/2016
ELDD  EPA-600/1-76-008 CCTE/GLTED Library/Duluth,MN 12/01/2000
NTIS  PB-251 670 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation ix, 75 pages ; 28 cm.
Abstract The report contains information concerning the mode of action, excretion, and metabolism of the cyclodiene insecticides. Toxaphene was the primary candidate for investigation with major emphasis on the mammalian system. Excretion of 36Cl-toxaphene was studied in the laboratory rat. Upon extraction, most of the radioactivity occurred in the water fractions of urine and feces as ionic chloride, indicating considerable metabolism of toxaphene. Occurrence of radioactivity in several tissues of Leucophaea maderae was determined after injections of 36Cl-toxaphene. Uptake of .00001M 36Cl-toxaphene in subcellular particles of ventral nerve cord and brain was studied and showed significant levels in the larger cell fragments. The toxicity syndrome of toxaphene to Gambusia affinis was divided into five stages, and the residue level at each stage was determined. Excretion was not observed. Metabolic alteration of toxaphene appeared to be minimal. Ventral nerve cords of Periplaneta americana and L. maderae showed increased nerve activity as viewed electrophysiologically when exposed to toxaphene. Toxaphene appeared to be a neurotoxicant.
Notes "January 1976." "EPA/600-1-76-008." "Project no. R-800384." Includes bibliographical references.
Place Published Washington, D.C.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.); United States. Environmental Protection Agency. Office of Research and Development.
Title Ser Add Ent Research reporting series. Environmental health effects research ; EPA-600/1-76-008.
PUB Date Free Form 1976
Series Title Traced Environmental health effects research series ;
Series Title Untraced Environmental health effects research series ; EPA-600/1-76-008
NTIS Prices PC A05/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
Merged OCLC records 8775365
OCLC Time Stamp 20160819053500
Language eng
SUDOCS Number EP 1.23/4:600/1-76-008
Origin OCLC
OCLC Rec Leader 01932cam 2200517Ia 45010