Main Title |
Support document, decision not to require testing for health effects : acrylamide / |
CORP Author |
United States. Environmental Protection Agency. Office of Toxic Substances. Assessment Division. |
Publisher |
U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, |
Year Published |
1980 |
Report Number |
EPA 560/11-80-016 |
Stock Number |
PB80-220312 |
OCLC Number |
08453100 |
Subjects |
Acrylamides--toxicity ;
Acrylamide--Toxicology ;
Hazardous substances
|
Additional Subjects |
Acrylamide--Toxicology ;
Hazardous substances ;
Physiological effects ;
Recommendations ;
Assessments ;
Laboratory animals ;
Nervous system ;
Signs and symptoms ;
Testing ;
Exposure ;
Toxic substances ;
Acrylamides ;
Toxic Substances Control Act ;
Public Law 94-469 ;
Neurotoxins
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJAD |
EPA 560/11-80-016 |
|
Region 3 Library/Philadelphia, PA |
03/20/1992 |
DISPERSAL |
EJED |
EPA 560/11-80-016 |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
ELBD ARCHIVE |
EPA 560-11-80-016 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ERAD |
EPA 560/11-80-016 |
|
Region 9 Library/San Francisco,CA |
09/04/2012 |
ESAD |
EPA 560-11-80-016 |
|
Region 10 Library/Seattle,WA |
09/10/2004 |
NTIS |
PB80-220312 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
33 p. |
Abstract |
It has been found that acrylamide is neurotoxic, producing central-peripheral axonopathies. The animal species in which this effect was demonstrated include rats, mice, cats, dogs, baboons, and monkeys. In addition, there are at least 48 published cases of the occupational toxicity and 5 cases of the nonoccupational toxicity of acrylamide to humans, many of whom manifested a measurable degree of neurotoxicity (central-peripheral axonopathy). In humans, the predominant signs of neurotoxicity are related to peripheral nerve involvement and, to a lesser extent, central nervous system involvement. A variety of other signs and symptoms also are generally reported, the most common ones occurring in the skin, hands, and feet. The onset of effects may be reversible, although this is not always the case. Based on laboratory data, EPA has concluded that acrylamide is a potent neurotoxicant at very low levels. This conclusion has been substantiated by a 1-year (oral administration) study in cats indicating a no-effect level of 0.3-1.0 mg/kg/day. EPA does not plan to require the health effects testing recommended by the Interagency Testing Committee. Instead, EPA plans to evaluate acrylamide for possible regulatory controls. |
Notes |
Cover title: Assessment of testing needs : acrylamide : support document for decision not to require testing for health effects, Toxic Substances Control Act, Section 4. "EPA-560/11-80-016." "June 1980." |
Place Published |
Washington, D.C. |
Access Notes |
Also issued online. |
Title Ser Add Ent |
TSCA chemical assessment series. |
Alternate Title |
Acrylamide\ Assessment of testing needs, acrylamide |
PUB Date Free Form |
1980 |
Series Title Traced |
TSCA chemical assessment series |
Series Title Untraced |
TSCA chemical assessment series |
Ti Tra Differently |
Acrylamide Assessment of testing needs, acrylamide |
NTIS Prices |
PC A03/MF A01 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
Merged OCLC records |
7364375 |
OCLC Time Stamp |
20120830171646 |
Language |
eng |
SUDOCS Number |
EP 5.15/2:Ac 7 |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01935cam 2200433 a 45020 |