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RECORD NUMBER: 8 OF 964

OLS Field Name OLS Field Data
Main Title 5-Methylhexanoic Acid Developmental Toxicity Testing.
Author Narotsky., M. G. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Jan 91
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/1-91/001;
Stock Number PB91-141838
Additional Subjects Toxicity ; Aliphatic acids ; Valproate ; Teratogens ; Rats ; Dose-response relationships ; Females ; Body weight ; Tables(Data) ; Reproduction(Biology) ; Litter size ; Structure-activity relationship ; Parturition ; 5-Methylhexanoic acid
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-141838 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 23p
Abstract As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 5-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by reduced weight gains, altered respiration (rales, dyspnea) and death. Body weight losses early in the treatment period were also evident at 400 mg/kg. In spite of the marked maternal toxicity present, there were no clear developmental effects; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups also revealed no compound effects.
Supplementary Notes Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
Category Codes 57Y; 57Q
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 107432797
Origin NTIS
Type CAT